#0031 Effects of obesity, metabolic syndrome, and non-alcoholic or alcoholic elevated liver enzymes on incidence of diabetes following lifestyle intervention: A subanalysis of the J-DOIT1
Identifying Target Groups for Managing Diabetes Through Lifestyle Interventions: Insights from a Randomized Controlled Trial
Type 2 diabetes is now a global health concern. With no treatment options that lead to a cure, managing the symptoms is usually one of the most common clinical approaches to controlling the disease. Even before the onset of diabetes, those deemed to be at a higher risk of developing it are often advised to implement lifestyle changes to manage their blood sugar levels.
This advice can come in the form of constant support and periodic guidance by a healthcare professional. However, for the cost-effective implementation of such outreach—for instance, support through phone calls—it is necessary to determine not only the correct strategies for delivering the support but also the target population for whom the strategies would work best.
To this end, several studies have been conducted worldwide. In Japan, we launched the Japanese Diabetes Outcome Intervention Trial-1, a randomized controlled trial involving 2607 prediabetic people with impaired fasting glucose (IFG). Our goal was to find out if lifestyle support delivered through phone calls could help reduce the incidence of diabetes. The participants placed in the intervention group received telephonic lifestyle support on exercise habits, weight, diet, and alcohol consumption for a year. Following this, their health conditions were tracked for an average of approximately five years.
At the end of the follow-up period, we found that participants who were also overweight, had metabolic syndrome, or alcoholic or non-alcoholic fatty liver disease, had a two- to three- fold higher incidence of diabetes. Further, the intervention only worked among participants who had non-alcoholic elevated liver enzymes. This meant that prediabetic people with IFG who also had non-alcoholic fatty liver disease or “unexplained” elevated liver enzymes were a good target population for cost-effective lifestyle interventions.
Link to the original journal article:
https://onlinelibrary.wiley.com/doi/full/10.1002/1348-9585.12109
Title of the paper:
Effects of obesity, metabolic syndrome, and non-alcoholic or alcoholic elevated liver enzymes on incidence of diabetes following lifestyle intervention: A subanalysis of the J-DOIT1
Authors:
Naoki Sakane, Kazuhiko Kotani, Akiko Suganuma, Kaoru Takahashi, Juichi Sato, Sadao Suzuki, Kazuo Izumi, Masayuki Kato, Mitsuhiko Noda, Shinsuke Nirengi, Hideshi Kuzuya
